You may have heard the term CB1 thrown around before in the cannabis industry. But what exactly is CB1 and what does it mean for cannabis users? This short guide will answer your most frequently asked questions about CB1, so you can be informed the next time you come across this mystery marijuana terminology.
What is CB1?
Our body has an endocannabinoid system housing an extensive expression of receptors located throughout both the central and peripheral nervous systems. CB1 and CB2 are two major receptors with CB1 in the brain and central nervous system and CB2 primarily in the peripheral organs. CB2 is found primarily outside of the brain whereas CB1 is found mostly in the brain and spread throughout the body. CB1 receptor function helps adjust and manage our limbic system and reward pathway of the brain.
THC Binds to What Receptor?
When a THC cannabinoid enters our body, it binds to CB1 receptors. As a result, THC affects CB1 receptors and the systems they control, producing a cerebral effect. See the graphic, “Distribution of CB1 Receptors in Brain” for details on impacted areas. When THC binds to cannabinoid receptor type 1, it impacts dopamine and constructs the ability to experience euphoria.
This Occurs When Cannabinoid Receptors Activate THC
Our bodies produce a natural cannabinoid neurotransmitter called anandamide. Bound cannabinoid receptors activate THC which makes our body mimic anandamide. Keep in mind, CB1 has nearly 20 times as many opioid receptors than any other type. So, this activates our brain’s neurons with natural marijuana-like effects throughout our mind and body.
What Receptors Does CBD Bind to?
CBD binds to vanilloid receptors. These are known as TRPV1 or transient receptor potential vanilloid subfamily, member 1. Vanilloid receptors also function as ion channels. TRPV1 mediates pain perception, inflammation, as well as body temperature. When CBD interacts with TRPV1, it impacts these receptors in our body making pain relief and reducing inflammation possible.
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